Senior Clinical Research Associate (CRA I/II) – Cape Town

About the role

Syneos Health is seeking a Senior Clinical Research Associate (CRA I/II) to join its Clinical Solutions team, preferably based in Cape Town. You will support drug development projects by ensuring sites meet regulatory and protocol standards throughout the study lifecycle.

Key responsibilities

• Perform site qualification, initiation, interim monitoring, and close‑out visits, either on‑site or remotely.
• Ensure compliance with ICH‑GCP, Good Pharmacoepidemiology Practices (GPP), and study protocols.
• Evaluate overall site performance, provide recommendations, and promptly escalate serious issues.
• Verify informed consent processes and protect patient confidentiality.
• Assess safety, data integrity, protocol deviations, and pharmacovigilance concerns at investigator sites.
• Conduct source document reviews and support site management plans.

Required profile

• Experience as a CRA I or II in clinical trials.
• Strong knowledge of ICH‑GCP guidelines and applicable regulatory requirements.
• Ability to assess site processes and develop corrective action plans.
• Excellent communication skills for interaction with site staff and internal teams.

Required skills

• ICH/GCP knowledge
• Good Pharmacoepidemiology Practices (GPP)
• Clinical monitoring and site management
• Source document review
• Pharmacovigilance awareness

What we offer

• Career development and progression opportunities.
• Supportive line management and peer recognition.
• Technical and therapeutic area training.
• Inclusive culture focused on delivering impact.